Matlacha is easy to reach from Interstate Route 75!
Take the Bayshore Drive exit 143 if you are coming from the north. Follow this road, which turns into Pine Island Road, all the way into Matlacha.
If you are coming from the south, take the State Road 884 W exit 136 toward Fort Myers/Cape Coral/Hospital. SR884 becomes Colonial Bouldevard which then becomes Veterans' Parkway. Follow Veterans' Parkway for about 10 miles and you will come to Pine Island Road NW. Turn left and you will soon enter Matlacha.